- 2 years, 2 months ago DavidsParticipant@davids
I found this artile which takes about the endocannabinoid system consisting of two main specialized receptors – cannabinoid 1 (CB1) and cannabinoid 2 (CB2). CB1 receptors are primarily found in the brain and throughout the central nervous system, while CB2 receptors are located mostly in the immune system, spleen, and their associated structures (Parcher, Batkai & Kunos, 2006) (Reggio, 2010).
These two cannabinoid receptors respond differently to different cannabinoids. THC is an agonist of both CB1 and CB2 receptors, but has a higher affinity for CB1. This means it binds directly with the two receptors and activates them (Parcher, Batkai & Kunos, 2006).
CBD, on the other hand, doesn’t bind directly to either CB1 or CB2 receptors. Instead, it acts indirectly against cannabinoid agonists. This means that CBD sits imperfectly inside the receptors, not activating them but effectively blocking THC and other chemical messengers from binding to those sites (Parcher, Batkai & Kunos, 2006).
CBD also interacts with various other receptors throughout the body, such as 5-HT1A receptors, which are linked to serotonin, and the vanilloid receptor TRPV1, which functions as an ion channel (Russo, et al., 2005) (Hassan, et al., 2014).
Here is the whole article, https://news.medicalmarijuanainc.com/cbd-effects-human-body/
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